Pyro-drive Jet Injector Actranza^™ lab. is a jet injector driven by the instantaneous power generated from pyro combustion. The high-speed stream of fluid ejected by Actranza^™ lab. penetrates skin, dispersing into intradermal tissue and introducing even large molecules into cells.

Product Profiles
Drug distribution and gene expression
Intracellular delivery with simple operation
Product specifications

Product Profiles

Available for administration to mice and rats
Minimally invasive
Small, light and easy to operate

Drug distribution and gene expression

Drug Distribution

The liquid disperses over a wide area in intradermal tissue (India ink).

Nuclear localization of plasmid DNA

Distribution to the nucleus of red fluorescent-labelled (Cy3) plasmid DNA (merged fluorescence which resembles pink granules is cell nuclei with blue fluorescent DAPI staining into which Cy3-labeled plasmid DNA has been introduced).

GFP gene expression

Expression of the gene encoding Green Fluorescence Proteins (GFP) by injection.

LacZ gene expression

Expression of the gene encoding β-galactosidase by injection of plasmid DNA (blue areas are expression sites).

Intracellular delivery with simple operation

1Control Unit
- Easy-to-grip
- Reusable
- Safety mechanism to prevent accidental injection
2Actuator
- Cartridge-type
- Single use
3Container Unit
- Includes loading adaptor
- Electron beam irradiated
- Single use

Product specifications

Dimension	150mm×57mm×35mm
Weight	140g
Power source	AC (100-240V)
Actuator type	Mouse, Rat
Volume	10µL, 20µL, 30µL, 50µL

Product lineup

Product name		Qty/box	Product code
Actuator	Mouse	5pcs.	AL-1A1MD-J5
Actuator	Rat	5pcs.	AL-1A1RD-J5
Container Unit with loading adaptor*	10µL	5pcs.	AL-1C10-J5
	20µL	5pcs.	AL-1C20-J5
	30µL	5pcs.	AL-1C30-J5
	50µL	5pcs.	AL-1C50-J5
Control Unit with AC adaptor			AL-P1A

*Container unit's product names are numbers based on container unit capacity. It does not indicate the dosage.

This device is for experimental animal studies only.
This device is not a medical device nor its accessory, which is not intended for any other purposes including the diagnosis, therapeutic intervention or prevent of disease in human or animals.
This device is specially designed and constructed for research purposes for temporary use in laboratories, which should not be permanently installed nor used in the laboratories for any other purposes after completion of such research projects.

Publications

Phase I Study to Assess the Safety and Immunogenicity of an Intradermal COVID-19 DNA Vaccine Administered Using a Pyro-Drive Jet Injector in Healthy Adults, Hironori Nakagami et al., Vaccines 2022, 10(9), 1427.
https://doi.org/10.3390/vaccines10091427
Immune response induced in rodents by anti-CoVid19 plasmid DNA vaccine via pyro-drive jet injector inoculation, Tomoyuki Nishikawa et al., Immunological Medicine, Volume 45, 2022 - Issue 4, Pages 251-264.
https://doi.org/10.1080/25785826.2022.2111905
Induction of potent antitumor immunity by intradermal DNA injection using a novel needle-free pyro-drive jet injector, Shinya Inoue et al., Cancer Science, Volume114, Issue1, January 2023, Pages 34-47.
https://doi.org/10.1111/cas.15542
Development of Pyro-Drive Jet Injector With Controllable Jet Pressure, H.Miyazaki et al., Journal of Pharmaceutical Sciences. 2019 Jul;108(7): 2415-2420.
https://doi.org/10.1016/j.xphs.2019.02.021
Stable Immune Response Induced by Intradermal DNA Vaccination by a Novel Needleless Pyro-Drive Jet Injector, C.Chang et al., AAPS PharmSciTech. 21, Article number: 19 (2020) .
https://doi.org/10.1208/s12249-019-1564-z
Anti-CoVid19 plasmid DNA vaccine induces a potent immune response in rodents by Pyro-drive Jet Injector intradermal inoculation, Tomoyuki Nishikawa et al., bioRxiv, Posted January 14, 2021.
https://doi.org/10.1101/2021.01.13.426436
Gene transfer by pyro-drive jet injector is a novel therapeutic approach for muscle diseases,Takafumi Nakae et al., Gene. Volume 788, 1 July 2021, 145664.
https://doi.org/10.1016/j.gene.2021.145664
Mechanism of jet injector-induced plasmid DNA uptake: Contribution of shear stress and endocytosis, Hiroshi Miyazaki et al., International Journal of Pharmaceutics. Volume 609, 20 November 2021, 121200.
https://doi.org/10.1016/j.ijpharm.2021.121200
Estimation of High-Speed Liquid-Jet Velocity Using a Pyro Jet Injector, Naohisa Takagaki et al., Scientific Reports Rep 9, 19859 (2019).
https://doi.org/10.1038/s41598-019-56511-x
“Section 6: Development of a novel needle-free device to administer DNA vaccines”, Developments in immunology and their applications that every researcher in industry and academia should know, Hiromitsu Iga, Takamasa Suzuki, Hiroshi Miyazaki, (Japan, Technical Information Institute Co. LTD, 2021)