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Preparation of bitterness masking ODTs

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Preparation of bitterness masking ODTs

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Bitterness masking with β-cyclodextrin.
Formulation of ODT with mitiglinide Ca.

Abstract

In this white paper, we report the preparation of an ODT including a　β-Cyclodextrin (β-CD)-masked Mitiglinide Ca (MIT). The ODT was prepared with the βCD/MIT complex and GRANFILLER-D. It showed excellent tablet hardness and disintegration even when high content of β-CD/MIT complex was applied. Furthermore, the ODT showed similar disintegration time with higher tablet hardness than the originator's drug.

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White Paper title	Preparation of bitterness masking ODTs

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White Paper

Preparation of bitterness masking ODTs

Topics covered in this white paper

Abstract

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