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Preparation of bitterness masking ODTs

Topics covered in this white paper

  • Bitterness masking with β-cyclodextrin.
  • Formulation of ODT with mitiglinide Ca.


In this white paper, we report the preparation of an ODT including a β-Cyclodextrin (β-CD)-masked Mitiglinide Ca (MIT). The ODT was prepared with the βCD/MIT complex and GRANFILLER-D. It showed excellent tablet hardness and disintegration even when high content of β-CD/MIT complex was applied. Furthermore, the ODT showed similar disintegration time with higher tablet hardness than the originator's drug.

Bitterness masking

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White Paper title Preparation of bitterness masking ODTs

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