White Paper
Please fill in the form below to request Applicability of co-processed excipients to continuous manufacturing: Dry granulation.
Applicability of co-processed excipients to continuous manufacturing: Dry granulation
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Abstract
Continuous Manufacturing (CM) is a manufacturing process in which raw or formulated materials are continuously fed into a processing line while the product is continuously discharged. Co-processed excipients seem to be suitable to CM as they can reduce numbers of control parameters required to maintain appropriate quality. In This white paper, the application of HiSORAD™ (HSR) to CM of(ODTs) is validated. Raw materials containing HSR were able to be granulated by the dry granulator and the particle size distribution was monitored in real time by the PAT tool. The obtained granules were tableted by the rotary tableting machine. The ODTs with HSR showed good compactability even at high API dosage and low compression force. It was found that API particle was uniformly dispersed in both granules and the tablet. HSR is expected to have high applicability for dry granuration system in CM since it is unlikely to cause separation and segregation of API.
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