White Paper
Please fill in the form below to request GRANFiLLER-D™-Water absorption behavior and disintegration mechanism-.
GRANFiLLER-D™-Water absorption behavior and disintegration mechanism-
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Abstract
'In this white paper, we report the water absorption behavior and disintegration mechanism of GRANFILLER-D™ (GNF). The real-time observations by X-ray was performed to investigate absorption behavior of ODTs prepared with several co-processed excipients (CPEs) . We found that ODTs with GNF showed distinctive smooth and homogeneous water absorption behavior disintegrating directly at a primary particle level. Additionally, the relation between porosity and disintegration time of ODTs with various CPEs was investigated by M. Kokott, et al. It was shown that ODT with GNF maintains short disintegration time over a wide range of porosity, unlike other CPEs. These investigations revealed that GNF particles themselves function as a water absorption pathway which is an unconventional water conducting pathway.
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