HiSORAD™

HiSORAD™ is a co-processed excipient for orally disintegrating tablets, ODTs. It has a particularly high compactability.

ODT with HiSORAD™ is quickly disrupted by contact with water.

ODT with HiSORAD™ is quickly disrupted by contact with water.

HiSORAD™ Features

HiSORAD™ is a co-processed excipient for ODTs. It consists of "D-Mannitol", "Microcrystalline cellulose" and "Croscarmellose sodium". HiSORAD™ has excellent compactability so that high tablet hardness is possible at low compression force. Even with high API content and coated granules, it provides sufficient tablet hardness and rapid disintegration.
HiSORAD™ contributes to the simplification and efficiency of ODT formulation design.

  • Excellent compactability for low compressible APIs and API pellets
  • Well-balanced tablet property between OD time and hardness
  • High API loading capacity
  • Simple composition

Regulation

  • All components of HiSORAD™ are included in JP, USP and EP.
  • US-DMF is available for HiSORAD™.

Powder properties

The particles of HiSORAD™ has non-spherical shape since it is processed by our unique granulation method. This special shape contributes to good content uniformity.

SEM photograph of HiSORAD™

SEM photograph of HiSORAD™

Powder Properties

Items HSR-D03
Mean particle size※1 (Median) 106 μm
Density (Loose) 0.35 g/cm3
Density (Tapping) 0.49 g/cm3
Angle of repose 41 °
Orifice diameter 6.3 mm
Water content 2.4 wt%

※1 Measured by dry laser diffraction/scattering instrument​

Particle size distribution

Particle size distribution

Placebo tablet performance

Placebo tablets with HiSORAD™ are compatible with adequate tablet hardness and rapid disintegration. Compression force shows a higher tablet hardness even in the low region of compression force.

Tablet performance of placebo ODTs

Tablet performance of placebo ODTs

HiSORAD™ maintains good tablet performance even with high dose API.
Examples of high-dose ODT

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