Pyro-drive Jet Injector Actranza lab. is a jet injector driven by the instantaneous power generated from pyro combustion. The high-speed stream of fluid ejected by Actranza lab. penetrates skin, dispersing into intradermal tissue and introducing even large molecules into cells.

Product Profiles

  • Available for administration to mice and rats
  • Minimally invasive
  • Small, light and easy to operate

Drug distribution and gene expression

Drug Distribution

The liquid disperses over a wide area in intradermal tissue (India ink).

Nuclear localization of plasmid DNA

Distribution to the nucleus of red fluorescent-labelled (Cy3) plasmid DNA (merged fluorescence which resembles pink granules is cell nuclei with blue fluorescent DAPI staining into which Cy3-labeled plasmid DNA has been introduced).

GFP gene expression

Expression of the gene encoding Green Fluorescence Proteins (GFP) by injection.

LacZ gene expression

Expression of the gene encoding β-galactosidase by injection of plasmid DNA (blue areas are expression sites).

Intracellular delivery with simple operation

  1. 1Control Unit

    • Easy-to-grip
    • Reusable
    • Safety mechanism to prevent accidental injection
  2. 2Actuator

    • Cartridge-type
    • Single use
  3. 3Container Unit

    loading adaptor
    • Includes loading adaptor
    • Electron beam irradiated
    • Single use

Product specifications

Dimension 150mm×57mm×35mm
Weight 140g
Power source AC (100-240V)
Actuator type Mouse, Rat
Volume 10µL, 20µL, 30µL, 50µL

This product is for experimental animal studies ONLY. Product is not intended for any other purposes including the diagnosis, therapeutic intervention or prevention of disease in humans or animals.

Product lineup

Product name Qty/box Product code
Actuator Mouse 5pcs. 1A1MD-5
Rat 5pcs. 1A1RD-5
Container Unit
with loading adaptor
10µL 5pcs. 1C10-5
20µL 5pcs. 1C20-5
30µL 5pcs. 1C30-5
50µL 5pcs. 1C50-5
Control Unit with AC adaptor   P1GL
Related Links
  • Development of Pyro-Drive Jet Injector With Controllable Jet Pressure, H.Miyazaki et al.,Journal of Pharmaceutical Sciences. 2019 Jul;108(7):2415-2420. DOI: 10.1016/j.xphs.2019.02.021
    https://doi.org/10.1016/j.xphs.2019.02.021
  • Stable Immune Response Induced by Intradermal DNA Vaccination by a Novel Needleless Pyro-Drive Jet Injector, C.Chang et al.,
    AAPS PharmSciTech. 21, Article number: 19 (2020) . DOI: 10.1208/s12249-019-1564-z
    https://doi.org/10.1208/s12249-019-1564-z
  • DAICEL Participates in the Joint DNA Vaccine Development Against the New Coronavirus Conducted by Osaka University and AnGes, Inc. with Our Novel Drug Delivery Device, “ActranzaTM lab.” Technology
    https://www.daicel.com/en/news/assets/pdf/00000815-1.pdf
Contact
Daicel Corporation
Medical Device Division
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