Pyro-drive Jet Injector
Actranza® lab. is a jet injector driven by the instantaneous power generated from pyro combustion. The high-speed stream of fluid ejected by Actranza® lab. penetrates skin, dispersing into intradermal tissue and introducing even large molecules into cells.
Product Profiles
- Available for administration to mice and rats
- Minimally invasive
- Small, light and easy to operate
Drug distribution and gene expression
Drug Distribution
The liquid disperses over a wide area in intradermal tissue (India ink).
Efficient Delivery of Plasmid DNA into Cells
This shows that the fluorescently labeled (Cy3) plasmid DNA is efficiently taken up into the cells nucleus (pink fluorescent granules indicate the introduction of plasmid DNA into the cell nucleus).
GFP gene expression
Expression of the gene encoding Green Fluorescence Proteins (GFP) by injection.
LacZ gene expression
Expression of the gene encoding β-galactosidase by injection of plasmid DNA (blue areas are expression sites).
Intracellular delivery with simple operation
-
1Control Unit
- Easy-to-grip
- Reusable
- Safety mechanism to prevent accidental injection
-
2Actuator
- Cartridge-type
- Single use
-
3Container Unit
- Includes loading adaptor
- Electron beam irradiated
- Single use
Product specifications
| Dimension | 150mm×57mm×35mm |
|---|---|
| Weight | 140g |
| Power source | AC (100-240V) |
| Actuator type | Mouse, Rat |
| Volume | 10µL, 20µL, 30µL, 50µL |
Product lineup
| Product name | Qty/box | Product code | |
|---|---|---|---|
| Actuator | Mouse | 5pcs. | AL-1A1MD-J5 |
| Rat | 5pcs. | AL-1A1RD-J5 | |
| Container Unit with loading adaptor* |
10µL | 5pcs. | AL-1C10-J5 |
| 20µL | 5pcs. | AL-1C20-J5 | |
| 30µL | 5pcs. | AL-1C30-J5 | |
| 50µL | 5pcs. | AL-1C50-J5 | |
| Control Unit with AC adaptor | AL-P1A | ||
*Container unit's product names are numbers based on container unit capacity. It does not indicate the dosage.
- This device is for experimental animal studies only.
- This device is not a medical device nor its accessory, which is not intended for any other purposes including the diagnosis, therapeutic intervention or prevent of disease in human or animals.
- This device is specially designed and constructed for research purposes for temporary use in laboratories, which should not be permanently installed nor used in the laboratories for any other purposes after completion of such research projects.
Publications
- Phase I Study to Assess the Safety and Immunogenicity of an Intradermal COVID-19 DNA Vaccine Administered Using a Pyro-Drive Jet Injector in Healthy Adults, Hironori Nakagami et al., Vaccines 2022, 10(9), 1427.
https://doi.org/10.3390/vaccines10091427 - Immune response induced in rodents by anti-CoVid19 plasmid DNA vaccine via pyro-drive jet injector inoculation, Tomoyuki Nishikawa et al., Immunological Medicine, Volume 45, 2022 - Issue 4, Pages 251-264.
https://doi.org/10.1080/25785826.2022.2111905 - Induction of potent antitumor immunity by intradermal DNA injection using a novel needle-free pyro-drive jet injector, Shinya Inoue et al., Cancer Science, Volume114, Issue1, January 2023, Pages 34-47.
https://doi.org/10.1111/cas.15542 - Development of Pyro-Drive Jet Injector With Controllable Jet Pressure, H.Miyazaki et al., Journal of Pharmaceutical Sciences. 2019 Jul;108(7): 2415-2420.
https://doi.org/10.1016/j.xphs.2019.02.021 - Stable Immune Response Induced by Intradermal DNA Vaccination by a Novel Needleless Pyro-Drive Jet Injector, C.Chang et al., AAPS PharmSciTech. 21, Article number: 19 (2020) .
https://doi.org/10.1208/s12249-019-1564-z - Anti-CoVid19 plasmid DNA vaccine induces a potent immune response in rodents by Pyro-drive Jet Injector intradermal inoculation, Tomoyuki Nishikawa et al., bioRxiv, Posted January 14, 2021.
https://doi.org/10.1101/2021.01.13.426436 - Gene transfer by pyro-drive jet injector is a novel therapeutic approach for muscle diseases,Takafumi Nakae et al., Gene. Volume 788, 1 July 2021, 145664.
https://doi.org/10.1016/j.gene.2021.145664 - Mechanism of jet injector-induced plasmid DNA uptake: Contribution of shear stress and endocytosis, Hiroshi Miyazaki et al., International Journal of Pharmaceutics. Volume 609, 20 November 2021, 121200.
https://doi.org/10.1016/j.ijpharm.2021.121200 - Estimation of High-Speed Liquid-Jet Velocity Using a Pyro Jet Injector, Naohisa Takagaki et al., Scientific Reports Rep 9, 19859 (2019).
https://doi.org/10.1038/s41598-019-56511-x - “Section 6: Development of a novel needle-free device to administer DNA vaccines”, Developments in immunology and their applications that every researcher in industry and academia should know, Hiromitsu Iga, Takamasa Suzuki, Hiroshi Miyazaki, (Japan, Technical Information Institute Co. LTD, 2021)
Related News
- “Actranza™ lab.” will be released through the sales agent(June 14,2022)
- DAICEL provides Immunetune with “Actranza™ lab. technology” for their development of next generation DNA vaccines against cancer and infection diseases(April 22, 2022)
https://www.daicel.com/en/news/assets/pdf/20220422_2.pdf - Announcement of Investigator-Initiated Clinical Trial on COVID-19 DNA Vaccination Using Daicel's Novel Drug Delivery Device(January 8, 2021)
https://www.daicel.com/en/news/assets/pdf/20210108.pdf - DAICEL Participates in the Joint DNA Vaccine Development Against the New Coronavirus Conducted by Osaka University and AnGes, Inc. with Our Novel Drug Delivery Device, “Actranza™ lab.” Technology(March 13, 2020)
https://www.daicel.com/en/news/assets/pdf/00000815-1.pdf
Contact
DAICEL CORPORATION
Life Sciences Business Division
Life Sciences Business Division
Trademark Attribution
Actranza® lab. is a registered trademark of Daicel Corporation in Japan and other countries.